SKAP2

SKAP2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3OMH

Identifiers

SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP-HOM, SKAP55R, src kinase associated phosphoprotein 2

External IDs

MGI: 1889206 HomoloGene: 2919 GeneCards: SKAP2

Gene ontology
Molecular function	• protein binding • SH3/SH2 adaptor activity
Cellular component	• cytosol • plasma membrane • nucleoplasm • cytoplasm
Biological process	• immune response-activating signal transduction • B cell activation • protein complex assembly • signal transduction • negative regulation of cell proliferation • positive regulation of signal transduction
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


8935


54353


ENSG00000005020


ENSMUSG00000059182


O75563


Q3UND0

RefSeq (mRNA)


NM_003930 NM_001303468


NM_018773

RefSeq (protein)


NP_001290397.1 NP_003921.2


NP_061243.1

Location (UCSC)

Chr 7: 26.67 – 27 Mb

Chr 6: 51.86 – 52.01 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene.^[3]^[4]^[5]

The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T (Jan 1999). "RA70 is a src kinase-associated protein expressed ubiquitously". Biochem Biophys Res Commun. 252 (3): 738–42. doi:10.1006/bbrc.1998.9637. PMID 9837776.
↑ Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B (Oct 1998). "SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55". FEBS Lett. 435 (1): 55–60. doi:10.1016/S0014-5793(98)01040-0. PMID 9755858.
1 2 "Entrez Gene: SKAP2 src kinase associated phosphoprotein 2".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Liu J, Kang H, Raab M, et al. (1998). "FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8779–84. doi:10.1073/pnas.95.15.8779. PMC 21153. PMID 9671755.
Wang X, Stollar BD (1999). "Immunoglobulin VH gene expression in human aging". Clin. Immunol. 93 (2): 132–42. doi:10.1006/clim.1999.4781. PMID 10527689.
Asazuma N, Wilde JI, Berlanga O, et al. (2000). "Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin". J. Biol. Chem. 275 (43): 33427–34. doi:10.1074/jbc.M001439200. PMID 10942756.
Curtis DJ, Jane SM, Hilton DJ, et al. (2001). "Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest". Exp. Hematol. 28 (11): 1250–9. doi:10.1016/S0301-472X(00)00537-3. PMID 11063873.
Moog-Lutz C, Peterson EJ, Lutz PG, et al. (2001). "PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells". J. Biol. Chem. 276 (25): 22375–81. doi:10.1074/jbc.M011683200. PMID 11301322.
Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Takahashi T, Yamashita H, Nagano Y, et al. (2004). "Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation". J. Biol. Chem. 278 (43): 42225–33. doi:10.1074/jbc.M213217200. PMID 12893833.
Park SY, Avraham HK, Avraham S (2004). "RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner". J. Biol. Chem. 279 (32): 33315–22. doi:10.1074/jbc.M313527200. PMID 15166227.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PDB gallery

1u5e: Crystal Structure of a N-terminal Fragment of SKAP-Hom Containing Both the Helical Dimerization Domain and the PH Domain

1u5g: Crystal Structure of the PH Domain of SKAP-Hom

2otx: Crystal Structure of A N-terminal Fragment of SKAP-HOM Containing both the Helical Dimerization Domain and the PH Domain

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